Neurological Physical Therapy Laboratory

Professor in charge: Professor Ray-Yau Wang and Professor Yea-Ru Yang

Main research areas/interests:
The main goal of the neurological physical therapy laboratory is to investigate the mechanism, recovery, and effects of treatment for common neurological diseases and elderly population. Our laboratory uses balance, gait and motor equipments or instruments to measure an individual’s changes of motor control and function. In the recent years, we apply transcranial magnetic stimulation, ECoG detection, functional near-infrared spectroscopy, and motion detection systems to explain more details of underlining changes and mechanisms of brain after different interventions. Some of our research findings have been published on international SCI journals and Journal of the Physical Therapy Association of the R.O.C. The research projects which will be conducted in our laboratory will be emphasized on neural mechanisms for intervention in stroke or Parkinson’s patients. We also wish to explore ourselves into the research of different types of neurological disorders. The research outcomes obtained from our laboratory can be used as references in the assessing different neurological diseases, selecting treatment alternatives and evaluating the effects of treatment.

Research projects undergoing in these 3 years periods:
Research Projects Duration Funding organizations
Turning characteristics and turning-based treadmill training effects in subjects with chronic stroke 2011/01~2013/12 National Health Research Institutes
Virtual reality-enhanced optimal exercise training model for falls prevention and its remote applications in elderly with different fall risks 2011/08~2013/07 National Sciences Council
Optimized exercise model and remote training for fall prevention in elderly 2011/08~2013/07 National Sciences Council
Different training strategies for turning performance and fall risk in individuals with Parkinson disease 2013/01~2013/12 Cheng Hsin General Hospital
Effects of dual task on gait performance and brain activities-exploration of age and neurological diseases 2014/08~2017/07 Ministry of Science and Technology
The study of clinical noninvasive measurement of diaphragmatic function and neural control in individuals with chronic obstructive pulmonary disease and heart failure 2015/08~2016/07 Ministry of Science and Technology

Publications during the recent 5 years :

1. Laio YY, Yang YR, Cheng SJ, Wu YR, Fuh JL, Wang RY.Virtual reality-based training to improve obstacle crossing performance and dynamic balance in patients with Parkinson’s disease. Neurorehabil and Neural Repair, 29: 658-667, 2015. (SCI)
2. Lu CF, Liu YC, Yang YR, Wu YT, Wang RY. Maintaining gait performance by cortical activation during dual-task interference: a functional near-infrared spectroscopy study. PLoS One, 10: e0129390, 2015. (SCI)
3. Wang RY, Wang YL, Cheng FY, Chao YH, Chen CL, Yang YR. Effects of combined exercise on gait variability in community-dwelling older adults. Age, 37: 9780, 2015. (SCI) Online publish
4. Cheng SJ, Yang YR, Cheng FY, Chen IH, Wang RY. The changes of muscle strength and functional activities during aging in male and female population. Int J Gerontol, 8: 197-202, 2014. (SCI)
5. Chiou SY, Wang RY, Roberts RE, Wu YT, Lu CF, Liao KK, Yang YR. Fractional anisotropy in corpus callosum is associated with facilitation of motor representation during ipsilateral hand movements. PLoS One, 9: e104218, 2014. (SCI)
6. Yang YR, Chen YH, Chang HC, Chan RY, Wei SH, Wang RY. Effects of interactive visual feedback training on post-stroke pusher syndrome: a pilot randomized controlled study. Clin Rehabil, 2014. (SCI) In press
7. Wang YH, Yang YR, Pan PJ, Wang RY. Modeling factors predictive of functional improvement following acute stroke, J Chin Med Assoc, 77: 469-476, 2014. (SCI)
8. Laio YY, Yang YR, Wu YR, Wang RY. Virtual reality based Wii Fit training in improving muscle strength, sensory integration ability and walking abilities in patients with Parkinson’s disease: a randomized control trial. Int J Gerontol, 2014. (SCI) Accepted
9. Cheng FY, Yang YR, Wang CJ, Wu YR, Cheng SJ, Wang HC, Wang RY. Factors influencing turning and its relationship with falls in individuals with Parkinson’s disease. PLoS One, 9: e93572, 2014. (SCI)
10. Laio YY, Yang YR, Wu YR, Wang RY. Factors influencing obstacle crossing performance in patients with Parkinson’s disease. PLoS One, 9: e84245, 2014. (SCI)
11. Chen IH, Yang YR, Chan RC, Wang RY. Turning-based treadmill training improves turning performance and gait symmetry after stroke. Neurorehabil and Neural Repair, 28: 45-55 2014. (SCI)
12. Chiou SY, Wang RY, Tseng CY, Lin SY, Cheng SJ, Yang YR. Relationship between cortical activation and ambulation in patients with Parkinson’s disease. Formos J Phys Ther, 39: 18-24, 2014.
13. Chen IH, Yang RY, Cheng SJ, Chan RC, Wang RY. Neuromuscular and biomechanical strategies of turning in ambulatory individuals post-stroke. Chin J Physiol, 57: 128-136, 2014. (SCI)
14. Chiou SY, Wang RY, Liao KK, Yang YR. Homologous muscle contraction during unilateral movement does not show a dominant effect on leg representation of the ipsilateral primary motor cortex. PLoS One, 8: e72231, 2013. (SCI)
15. Dai CY, Huang YH, Chou LW, Wu SC, Wang RY, Lin LC. Effects of primary caregiver participation vestibular rehabilitation for unilateral neglect patients with right hemispheric stroke: a randomized controlled trial. Neuropsychiatr Dis Treat, 9: 477-484, 2013. (SCI)
16. Chiou SY, Wang RY, Liao KK, Wu YT, Lu CF, Yang YR. Co-activation of primary motor cortex ipsilateral to muscles contracting in a unilateral motor task. Clin Neurophysiol, 124: 1353-1363, 2013. (SCI)
17. Chen IH, Yang YR, Cheng SJ, Wang RY. Differences in kinematic and electromyographic characteristics between young and older adults during circular turning. Int J Gerontol, 7: 162-166, 2013. (SCI)
18. Yang YR, Tseng CY, Chiou SY, Liao KK, Cheng SJ, Lai KL, Wang RY. Combination of rTMS and treadmill training modulates corticomotor inhibition and improves walking in Parkinson’s disease: a randomized trial. Neurorehabil Neural Repair, 27: 79-86, 2013. (SCI)
19. Wang RY, Tseng HY, Liao KK, Wang CJ, Lai KL, Yang YR. rTMS combined with task-oriented training to improve symmetry of interhemispheric corticomotor excitability and gait performance after stroke: a randomized trial. Neurorehabil Neural Repair, 26: 222-230, 2012. (SCI)
20. Wang FY, Cheng FY, Lien IT, Wang RY, Yang YR. Systematic review and meta analysis: effects of ankle-foot orthoses on gait and function in patients with stroke. Formos J Phys Ther, 36: 274-284, 2011.
21. Yang YR, Lee YY, Cheng SJ, Wang RY. Downhill walking training in individuals with Parkinson’s disease: a randomized controlled trial. Am J Phy Med Rehabil, 89: 706-714, 2010. (SCI)
22. Tung FL, Yang YR, Lee CC, Wang RY. Balance outcomes after additional sit-to-stand training in subjects with stroke: a randomized controlled trial. Clin Rehabil, 24: 533-542, 2010. (SCI)
23. Yang YR, Chen IH, Liao KK, Huang CC, Wang RY. Cortical reorganization induced by body weight-supported treadmill training in patients with hemiparesis of different stroke durations. Arch Phys Med Rehabil, 91: 513-518, 2010. (SCI)
24. Cheng JS, Yang YR, Cheng SJ, Lin PY, Wang RY. Effects of combining electric stimulation with active ankle dorsiflexion while standing on a rocker board: a pilot study for subjects with spastic foot after stroke. Arch Phys Med Rehabil, 91: 505-512, 2010. (SCI)
25. Chiu CM, Huang SF, Tsai PY, Wang RY, Chuang TY, Sung WH. Computer-aided vestibular autorotational testing of the vestibulo-ocular reflex in senile vestibular dysfunction. Comput Methods Programs Biomed, 97: 92-98, 2010. (SCI)

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